264.The  smallest（slightest/modest）change（improvement/progress）can  produce（bring  about/lead  to）…

      265.Anyone  with  the  slightest（modest/least）knowledge（common  sense）of…knows（can  tell）that…

266.A  little（careful/better）study comparison/understanding/appreciation）of…can/will  help（promote/contribute  to）…  

267.Who  is  to  say  when/if…，or  even  to  say…

268.It  is  almost（hardly）impossible（inconceivable）that…without …  269.Hardly（Scarcely  anyone/Few  people）…without…  

270.You/One  cannot without…

271.It  doesn’t  matter（makes  no  difference）whether/that…  

272.No  matter  how…However 

      273.Whatever  the  causes/pressures/conditions，…

274.However  great  the  demand（urgent  the  need/laudable  the  de-sire/praiseworthy  the  effort）to…，and  however…  

275.The  more…;the  more…;the  more…

276…never（not/hardly）…let  alone（much  less/to  say  nothing  of/ not  to  speak/mention  of）…